A two-component, multimeric endolysin encoded by a single gene
نویسندگان
چکیده
منابع مشابه
Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin.
OBJECTIVES Streptococcus pyogenes, or Group A streptococcus (GAS), has a propensity to colonize human tissues and form biofilms. Significantly, these biofilms are a contributing mechanism of antibiotic treatment failure in streptococcal disease. In this study, we evaluate a streptococcal-specific bacteriophage-encoded endolysin (PlyC), which is known to lyse planktonic streptococci, on both sta...
متن کاملRapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin
Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin. Title Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin. Publication Type Journal Article Year of Publication 2013 Authors Shen, Y, Köller, T, Kreikemeyer, B, Nelson, DC Journal J Antimicrob Chemother Volume 68 Issue 8 Pagination 1818-24 Date Published 2...
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Gram-positive bacteria possess a thick cell wall composed of a mesh polymer of peptidoglycans, which provides physical protection. Endolysins encoded by phages infecting bacteria can hydrolyse peptidoglycans in the bacterial cell wall, killing the host bacteria immediately. The endolysin (Psm) encoded by episomal phage phiSM101 of enterotoxigenic Clostridium perfringens type A strain SM101 exhi...
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Background: Septins are members of highly conserved polymerizing GTP binding proteins well described in the animal kingdom. 14 Septin proteins have been characterized in humans (SEPT1-SEPT14), some of which are tissue-specific. All of 14 genome-mapped human septins contain a highly conserved central GTP-binding domain which is very critical in GTPase signaling properties as well as oligomerizat...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2014
ISSN: 0950-382X
DOI: 10.1111/mmi.12857